The Case for AI That Improves Itself | Deep Dives with a16z

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Matt Bornstein speaks with Mirendil cofounders Behnam Neyshabur and Harsh Mehta about their vision for building self-accelerating AI. After leading research efforts at Google and Anthropic, the founders started Mirendil around a simple question: what happens when AI systems can meaningfully contribute to their own development? Rather than focusing solely on AI as a tool for productivity, they argue that the most important application may be accelerating scientific and technological progress itself. The conversation explores AI research, scaling laws, automated engineering, scientific discovery, and the challenges of building systems that can improve over time. They discuss the future of AI-assisted research, why they believe scientific progress remains bottlenecked by intelligence, and how more capable AI systems could help unlock advances across medicine, engineering, and the natural sciences. Timestamps: 00:00 - Intro 01:10 - Meet Mirendil: Self-Accelerating AI for Science 03:11 - The Shortest Path to Accelerating Science 06:14 - What "Self-Accelerating AI" Actually Means 12:50 - From Anthropic to a Startup: The Origin Story 17:54 - Safety, Guardrails & Democratizing AI Research 22:02 - Giving Businesses Their Own AI 26:34 - Scaling Systems of Agents and Humans 35:53 - Where Does It All End? Science as the Goal Resources: Follow Behnam Neyshabur on X: https://x.com/bneyshabur?lang=en Follow Harsh Mehta on X: https://x.com/HarshMeh1a Follow Matt Bornstein on X: https://x.com/BornsteinMatt Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Show on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Show on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see http://a16z.com/disclosures.