#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

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<p>Manolis Kellis is a professor at MIT and head of the MIT Computational Biology Group. He is interested in understanding the human genome from a computational, evolutionary, biological, and other cross-disciplinary perspectives.</p> <p>Support this podcast by supporting our sponsors:<br /> &#8211; Blinkist: <a href="https://blinkist.com/lex">https://blinkist.com/lex</a><br /> &#8211; Eight Sleep: <a href="https://eightsleep.com/lex">https://eightsleep.com/lex</a><br /> &#8211; MasterClass: <a href="https://masterclass.com/lex">https://masterclass.com/lex</a></p> <p>If you would like to get more information about this podcast go to <a href="https://lexfridman.com/ai">https://lexfridman.com/ai</a> or connect with @lexfridman on <a href="https://twitter.com/lexfridman">Twitter</a>, <a href="https://www.linkedin.com/in/lexfridman/">LinkedIn</a>, <a href="https://www.facebook.com/lexfridman">Facebook</a>, <a href="https://medium.com/@lexfridman">Medium</a>, or <a href="https://www.youtube.com/lexfridman">YouTube</a> where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on <a href="https://podcasts.apple.com/us/podcast/artificial-intelligence/id1434243584">Apple Podcasts</a>, follow on <a href="https://open.spotify.com/show/2MAi0BvDc6GTFvKFPXnkCL">Spotify</a>, or support it on <a href="https://www.patreon.com/lexfridman">Patreon</a>.</p> <p>Here&#8217;s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time.</p> <p>OUTLINE:<br /> 00:00 &#8211; Introduction<br /> 03:54 &#8211; Human genome<br /> 17:47 &#8211; Sources of knowledge<br /> 29:15 &#8211; Free will<br /> 33:26 &#8211; Simulation<br /> 35:17 &#8211; Biological and computing<br /> 50:10 &#8211; Genome-wide evolutionary signatures<br /> 56:54 &#8211; Evolution of COVID-19<br /> 1:02:59 &#8211; Are viruses intelligent?<br /> 1:12:08 &#8211; Humans vs viruses<br /> 1:19:39 &#8211; Engineered pandemics<br /> 1:23:23 &#8211; Immune system<br /> 1:33:22 &#8211; Placebo effect<br /> 1:35:39 &#8211; Human genome source code<br /> 1:44:40 &#8211; Mutation<br /> 1:51:46 &#8211; Deep learning<br /> 1:58:08 &#8211; Neuralink<br /> 2:07:07 &#8211; Language<br /> 2:15:19 &#8211; Meaning of life</p>