Discovery

Patients Doing It for Themselves

<p>Patient power is on the rise. But is it rising too far? Frustrated by the time it takes to develop new drugs, the ethical barriers to obtaining clinical data or the indifference of the medical profession to obscure diseases, patients are setting up their own clinical trials and overturning the norms of clinical research. </p><p>A DIY clinical trial sounds like a joke – and a dangerous one at that. But as Vivienne Parry discovers, it's real and on the rise as greater access to medical data allows more patients to play research scientists and medics at their own game. </p><p>Patients lie at the very heart of clinical research – without them there is none. Yet they come way down the food chain when it comes to transparency about their own health, blinded as they usually are to what pills they are taking and whether they are actually doing them any good. Even after the trial is published they are left with little understanding of whether the treatment could work for them and licensing is usually years away. So it is perhaps hardly surprising that patient networks have sprung up to redress the balance. Much of this current patient led research now takes place through online communities, with activists and the articulate ill demanding more say in their treament. </p><p>Vivienne Parry looks at some examples of patient led research which have challenged the medical establishment. She also asks how far can this go: should patients be prevented from experimenting with proceedures or drugs that might kill them?</p><p>(Photo: Medicinal pills)</p>

Preventing Disease in Animals

<p>Diseases devastate livestock around the world. In chickens for example the deadly strain of bird flu and the lesser known bacterial infection Campylobacter, not only harms the chickens but is also a real threat to human health. </p><p>Melissa Hogenboom visits one of the world’s leading genetics institutions, the Roslin Institute in Edinburgh in the UK and hears about new genetic techniques to combat diseases in our livestock. In chickens, professor Helen Sang uses a subtle form of genetic modification, called genome editing. Her team is trying to find the genetic components of natural resistance in a wide group of chicken breeds, which they can then insert into the genome of livestock fowl in the hope of breeding healthier, safer chickens. They are close to making disease resistant birds but they are aware that GM animals are still a long way from entering the market in Europe. </p><p>Similar research is going on in cows for TB resistance, but here instead of genetically modifying they are cross-breeding which may take ten or more generations to complete. Melissa hears from Professor Liz Glass who studies the genetics of disease resistance in cattle. Her work has applications in the design of better vaccines for infectious diseases and understanding how disease spreads. </p><p>Melissa also hears about a team creating a frozen bio-bank of bird stem cells - cryopreserving them so that they could one day resurrect entire breeds. This technique could provide hope against losing these valuable genes forever. </p><p>Producer and presenter: Melissa Hogenboom </p><p>(Photo: Chickens. BBC copyright)</p>

Beyond the Abyss

<p>Rebecca Morelle talks to explorers of deep ocean trenches, from film-maker James Cameron to biologists discovering dark realms of weird pink gelatinous fish and gigantic crustaceans. </p><p>The deepest regions of the ocean lie between 6,000 and 11,000 metres. Oceanographers term this the Hadal Zone. It exists where the floor of abyss plunges into long trough-like features, known as ocean trenches. The Hadal zone is the final frontier of exploration and ecological science on the planet. </p><p>At its most extreme, the water pressure rises to 1 tonne per square centimetre and the temperature drops to 1 degree C. Despite the challenging conditions, some animals survive and thrive in the trenches. Because the technical challenges to operating there are so high, we are only now just learning what is down there and how creatures adapt to life in the extremes. </p><p>Based at the University of Aberdeen in Scotland, deep sea ecologist Alan Jamieson is one of the premier explorers of life in the Hadal zone. In the programme, he talks through some of the latest video footage he has from the depths of the Kermadec Trench in New Zealand - not by visiting in person but by dropping cameras on a deep sea probe called a hadal lander to the distant sea floor. The images were gathered on an expedition in April and May. They revealed new habits of hadal creatures. </p><p>Rebecca does talk to two people who have ventured in person to the far limit of the Hadal zone: US Navy Lieutenant Don Walsh who went down to the bottom of Challenger Deep in the Mariana Trench in 1960, and Hollywood director James Cameron who, 52 years later, repeated Walsh's voyage to 11,000 metres.</p><p>(Photo: Supergiant amphipod at 6200 metres. Credit: Oceanlab, University of Aberdeen)</p>

Power Transmission

<p>Gaia Vince looks at the future of power transmission. As power generation becomes increasingly mixed and demand increases, what does the grid of the future look like?</p>

Biosafety

<p>Accidents happen in science labs all over the world, but when you’re working with deadly pathogens the consequences can be disastrous. The reputation of America’s ‘gold standard’ The Centres for Disease Control and Prevention in Georgia has recently become tarnished as news emerged that 80 workers were inadvertently exposed to live anthrax, and a deadly strain of flu was accidentally sent to another lab. Further reports of tick-box safety culture, lethal samples sent in ziplock plastic bags and vials of smallpox from the 1950s being found in the back of a fridge have increased calls for a review of the work being done on some of the world’s most dangerous pathogens.</p><p>Andrew Luck-Baker looks at the impact of these recent biosafety lapses for BBC WS Discovery. Some scientists are now arguing for the reduction of laboratories working with deadly viruses and the closing down of research which is potentially risky. But does the benefit of the work outweigh its potential risks to the public? And how can human error be eliminated?</p><p>(Photo: Bio hazard warning symbol. Credit: Getty Images)</p>

Mum and Dad and Mum

<p>Alana Saarinen is a 13-year-old girl who lives with her mum and dad in Michigan, USA. She loves playing golf and the piano, listening to music and hanging out with friends. In those respects, she's like many teenagers around the world. Except she's not, because Alana is one of a handful of people in the world who have DNA from three people. </p><p>The BBC's Science Correspondent Rebecca Morelle explores how more children like Alana could be born. The UK is looking to legalise a new technique which would mean more children with DNA from three people could be born. This irreversibly changes the human genetic code, and would also eliminate debilitating genetic diseases. </p><p>This programme examines the safety and health implications of this new science. </p><p>For some it is controversial. For those who have these specific genetic diseases, it is the way to have their own healthy child. The UK is playing a pioneering role in developing the technique, called mitochondrial replacement, and Parliament are expected to vote on legalising it soon. If that happened, the UK would be the first place in the world to make the process legal. </p><p>But despite that, there are a small number of children in the world, like Alana Saarinen, who have DNA from three people already. Although a small sample, they could answer some of the questions people have, such as will they be healthy, do they feel like they have three parents and would they like to trace the donor one day in the future? </p><p>Producer: Charlotte Pritchard.</p>

Antibiotic Resistance Crisis - Part Two

<p>Infectious bacteria are becoming resistant to the drugs that used to kill them. The last new class of antibiotics was discovered in the 1980s. There is little in the development pipelines of the world’s pharmaceutical industry. Drug companies got out of antibiotics as their attention switched to much more lucrative daily medicines for chronic diseases. Public funding on antibiotic research has also withered. </p><p>Now that the gathering crisis of antibiotic resistance is becoming recognised by politicians, what are the options? Roland Pease explores how business, academia and governments might work together to avert a return to the medical dark ages.</p><p>Image Credit: Hospital scientist inspects an unidentified culture in the Microbiology Department of Sydney's Royal North Shore Hospital, Greg Wood/AFP/Getty Images</p>

Antibiotic Resistance Crisis - Part One

<p>The discovery and harnessing of antibiotic drugs in the mid-20th Century led some medics to predict the end of infectious diseases. But the bacteria fought and continue to fight back, evolving resistance to many of the drugs that used to kill them. Public health officials warn that without new drugs, medicine will return to the days where ‘a cut finger on Monday leads to death of Friday’. Without protective antibiotics to keep infections at bay, scores of standard surgical operations and chemotherapy for cancer will become too risky.</p><p>Roland Pease looks at scientific issues behind the gathering crisis. The last new class of antibiotics was discovered in the 1980s. Are there any others in the pipeline?</p><p>Image Credit: Hospital scientist inspects an unidentified culture in the Microbiology Department of Sydney's Royal North Shore Hospital, Greg Wood/AFP/Getty Images</p>

Cosmology

<p>In March astronomers in the BICEP2 collaboration announced they had found gravitational waves from the Big Bang. But now the evidence is being questioned by other scientists. </p><p>Dr Lucie Green reports on the debate and asks if scientists can ever know what happened billions of years ago when the universe was formed.</p><p>Image copyright: Steffen Richter, Harvard University</p>

Rosetta Mission Arriving At Comet

<p>On 6th August, the space probe Rosetta ends its 10 year journey and arrives at Comet 67P/Churyumov-Gerasimenko. If all goes well, Rosetta will be the first spacecraft to go into orbit around a comet. The European Space Agency probe will then accompany the comet until December 2015, studying the 4 kilometre-wide lump of ice and rock dust at a level of detail far surpassing any previous comet flyby.</p><p>In the words of Rosetta scientist Joel Parker, “Previous comet missions have been one-night stands, Rosetta will be there for a long term relationship.” </p><p>Rosetta will stay with 67P as it heads towards and around the other side of the Sun. Rosetta will be watching everything at close quarters as the comet heats up and produces the classic gas and dust comet tail.</p><p>In the final weeks of approach, the Rosetta team have realised this is going to be an even more interesting mission than they had supposed. In the middle of July, the probe’s camera revealed the bizzare shape of the comet’s nucleus. It appears to be formed of two objects joined together. Some have described it as having the shape of a toy duck. In November, Rosetta will send a small robot lander, Philae, down onto the comet’s surface – another hugely ambitious feat, given the feeble gravitational pull of the comet and its complex shape. Philae could bounce off into the void if its trajectory is not quite true and its on-board harpoons fail to secure it to the comet’s icy surface. </p><p>Discovery looks ahead to the mission’s key moments and big science questions with planetary scientists and members of the Rosetta science team: </p><p>Professor Ian Wright - principal investigator (PI) for the lander’s Ptolemy instrument, Professor Monica Grady - planetary scientist at the Open University, UK. Matt Taylor, project scientist on Rosetta Dr Joel Parker - deputy PI for Rosetta’s Alice spectrometer Dr Holger Sierks - principal investigator for Rosetta’s Osiris camera Dr Stephan Ulamec - project scientist for the lander Philae (German Space Agency) </p><p>The big questions for Rosetta include: did comets bring water and the essential ingredients for life to the early Earth?</p><p>Presented and produced by Andrew Luck-Baker Image Credit: Rosetta and Philae at Comet, European Space Agency</p>

Professor Sir Michael Rutter

<p>Professor Sir Michael Rutter has been described as the most illustrious and influential psychiatric scientist of his generation. His international reputation has been achieved despite the fact that as a young doctor, he had no intention of becoming a researcher, nor interest in becoming a child psychiatrist. In fact he became a world leader as both. </p><p>His career has spanned more than five decades and is marked by a remarkable body of high-impact research and landmark studies. The theme running through all his work has been child development, on the subtle interplay between nature and nurture and on the factors that make the difference between a child flourishing, or floundering. </p><p>Evacuated during World War Two, to a Quaker family in the USA, Mike Rutter tells Jim al-Khalili about the impact this move, aged seven, had on him. He describes the inspirational teachers who persuaded him that research and clinical work as a child and adolescent psychiatrist, was for him, and he admits that an early mentor insisted he mustn't receive any formal training in child psychiatry, something he hasn't received to this day! </p><p>He was awarded this country's first ever professorship in child psychiatry in 1973 and he's credited with founding the field of developmental psychopathology. This involves the study, over time, of normal and abnormal child development. He's currently Professor of Developmental Psychopathology at King's College, London and still a practicing child psychiatrist. </p><p>An early breakthrough was his discovery that autism, or inifantile psychosis as it was then known, had a genetic basis, something barely suspected at the time. </p><p>Beautifully designed studies of populations over time followed, many of them landmark studies still cited today. They established the framework for studying and investigating mental illness in the community. The Isle of Wight Studies (1964-74) surveyed the mental health of children living on the island and for the first time in such research, children themselves were directly interviewed and questioned. Before this, Mike Rutter tells Jim, the assumption had been that what children thought and said didn't really matter. </p><p>In the 1970s, the Fifteen Thousand Hours study, delivered ground-breaking evidence about the combination of factors that affected the performance and behaviour of children in inner city secondary schools. Findings from this study were included by both the Labour and Conservative parties in their 1979 election manifestos. </p><p>"Maternal Deprivation Reassessed" was Mike Rutter's challenge to John Bowlby's hugely influential theory of maternal attachment. It was described as "a classic in the field of childcare" and it transformed the debate about the relationships that help babies to flourish. </p><p>His fascination with the underlying reasons why and how children vary in their ability to weather and cope with adversity, led to the growth of resilience science. For more than 40 years Mike Rutter, "the intellectual father", has led this field of study. </p><p>His name is particularly associated with "natural experiments" and one of the best known is the English Romanian Adoptees study that he set up in the early 1990s and still runs today. The children being followed are those rescued from the orphanages of Nicolai Ceausescu and adopted by families in this country. Because of the appalling conditions many of these babies and toddlers experienced in Romanian institutions, Professor Rutter understood that tracking and studying them as they grew up in loving homes here, would provide important insights into how early deprivation affects childrens' development. </p><p>Producer: Fiona Hill</p><p>Image: Professor Sir Michael Rutter, BBC Copyright</p>

What has Happened to El Nino?

<p>At the start of 2014 meteorologists warned of a possible El Nino event this year. The portents were persuasive – a warming of the central Pacific much like that which preceded the powerful El Nino event of 1997. But since then the Pacific climate system seems to have stalled. What’s going on? What are the prospects for an El Nino to develop later this year? What impacts might it have? Roland Pease delves below the Pacific surface to find out what drives El Nino cycles, the most powerful single climate fluctuation on the planet, and asks the experts why it is so hard to forecast. “The year started with a bang,” one expert tells Discovery - will it end with a whimper?</p><p>(Photo: Burned swamp forest in Kalimantan. Credit: Florian Siegert, RSS GmbH)</p>

Swarming Robots

<p>Adam Hart looks at how new developments in understanding insect behaviour, plant cell growth and sub cellular organisation are influencing research into developing robot swarms. </p><p>Biological systems have evolved elegant ways for large numbers of autonomous agents to govern themselves. Staggering colonies built by ants and termites emerge from a decentralized, self-governing system: swarm intelligence. Now, taking inspiration from termites, marine animals and even plants, European researchers are developing autonomous robot swarms, setting them increasingly difficult challenges, such as navigating a maze, searching for an object or surveying an area. At the same time, an American team has announced that its group of robots can autonomously build towers, castles and even a pyramid. </p><p>Adam Hart reports on the latest developments in controlling groups of robots, and asks why models taken from the behaviour of social insects such as bees, ants and termites may be far more complex than previously thought. He also delves deep into the cells of plants looking at how the physical and chemical triggers for plant growth might be useful in robot design.</p><p>Image: Presenter Adam Hart with ‘Swarmbots’ at Britain’s Surrey University, BBC Copyright</p>

Anaesthesia

<p>General anaesthetics which act to cause reversible loss of consciousness have been used clinically for over 150 years. Yet scientists are only now really understanding how these drugs act on the brain and the body to stop us feeling pain. Linda Geddes reports on the latest research using molecular techniques and brain scanners. </p><p>Linda visits the Anaesthesia Heritage Centre where William Harrop-Griffiths, president of the Association of Anaesthetists of Great Britain and Ireland, tells her about the discovery of agents that knock us out. And, as an operation takes place in the Royal United Hospital in Bath, professor Tim Cook explains the role of the anaesthetist. </p><p>Linda also talks to professor Nick Franks of Imperial College, London, about his research into how anaesthetics work at the level of the cell. Irene Tracey, professor of Anaesthetic Science at Oxford University, discusses how her fMRI scans of people as they slowly undergo anaesthesia have revealed how the brain switches off. Professor Steven Laureys, head of the Coma Science Group at Liege Universiy in Belgium, explains how understanding anaesthesia can help coma patients and what it tells us about the difficult question of human consciousness.</p>

Janet Hemingway

<p>Janet Hemingway, the youngest woman to ever to become a full professor in the UK, talks about her career at the frontline of the war on malaria. Whilst many researchers look for vaccines and treatments to this global killer, Janet's approach, as a trained entomologist, has been to fight the mosquito - the vector - which transmits the malaria parasite.</p><p>Image: Janet Hemingway, BBC Copyright</p>

Ageing and the Brain

<p>Geoff Watts investigates the latest thinking about our brain power in old age. He meets researchers who argue that society has overly negative views of the mental abilities of the elderly - a dismal and fatalistic outlook which is not backed up by recent discoveries and theories. Geoff talks to professor Lorraine Tyler who leads a large study in Cambridge (CamCAN) which is comparing cognition and brain structure and function in 700 people aged between 18 and 88 years old. </p><p>He also meets scientists and participants involved in a unique study of cognition and ageing at the University of Edinburgh. It has traced hundreds of people who were given a nationwide intelligence test as children in 1932 and 1947. Since the year 2000, the study has been retesting their intelligence and mental agility in their 70s to 90s. The Lothian Birth Cohort study is revealing what we all might do in life to keep our minds fast and sharp well into old age. </p><p>One new and controversial idea holds that cognitive decline is in fact a myth. A team in Germany, led by Michael Ramscar, argues that older people perform less well in intelligence and memory tests because they know so much more than younger subjects and not because their brains are deteriorating. Simply put, their larger stores of accumulated knowledge slow their performance. Their brains take longer to retrieve the answers from their richer memory stores. </p><p>Producer: Andrew Luck-Baker</p>

Driverless Cars

<p>Jack Stewart meets the engineers who are building vehicles that drive themselves. He has a ride in Google's driverless car, which has no steering wheel and no pedals. Google's Chris Urmson explains the company's approach to autonomous vehicles. </p><p>Jack visits Stanford University's driverless car project where professor Chris Gerdes shows him Shelley, an automated Audi that races around a track at speed as well as a human driver. Chris is collaborating with a philosopher to explore some of the difficult questions around autonomous vehicles, such as who is liable if there's an accident. Is it the human or the car? And ,Jack meets Josh Swirtes whose company, Peloton, is linking trucks together with the idea that they should have fewer accidents. </p><p>(Photo: Jack Stewart in Stanford's University X1)</p>

Driverless Cars

<p>Most traffic accidents are caused by human error. Engineers are designing vehicles with built in sensors that send messages to other cars, trucks, bikes and even pedestrians, to prevent collisions happening. The idea is to make the vehicles react to whatever's going on faster than the human drivers. </p><p>Jack Stewart drives around the university town of Ann Arbor, in Michigan, in some of the many vehicles that are fitted with experimental devices in the world's largest connected vehicles project. He finds out how the system works from researchers at UMTRI, the University of Michigan's Transportation Research Institute, including the director, professor Peter Sweatman and human factors expert Dr Jim Sayer, Kirk Steudle, Director, Michigan Department of Transportation and a resident who has had her car fitted with an experimental device. </p><p>(Photo: Right hand wing mirror, Nevada, USA, BBC copyright)</p>

Taming the Sun

<p>ITER is the most complex experiment ever attempted on this planet. Its aim, to demonstrate that nuclear fusion, the power of the Sun, can give us pollution free energy that we can use for millions of years. But at the moment, it's still largely a vast building site in the Haut Provence of southern France, with little prospect of any nuclear reactions there for another decade. A recent management report made damning criticisms of the way ITER is run, of the relations between the central organisations, and the seven partners (USA, Russia, Japan, China, South Korea, India and Europe) contributing to the project. Roland Pease has been to Cadarache to see how work is progressing, and to hear of the hopes of the scientists who have dedicated their working lives to the dream. </p><p>(Photo: The empty magnet-winding hall at ITER, BBC copyright)</p>

Beauty and the Brain

<p>Dr Tiffany Jenkins asks what our brains can tell us about art. Can there ever be a recipe for beauty? Or are the great works beyond the powers of neuroscience? </p><p>She talks to Professor Semir Zeki of University College London, the first person to coin the term, neuroaesthetics, about what happens in the brain when people in a scanner see paintings or hear music. </p><p>Professor Gabi Starr at New York University tells Tiffany Jenkins why she thinks there are parts of the brain that light up when we like an art work. </p><p>Tiffany visits Christie's auction house to explore whether the best art always commands the best prices.</p><p>She also talks to Martin Kemp, Emeritus Professor of Art History at Oxford University, about our different responses to authentic paintings and to fakes. </p><p>And Tiffany discusses with art critic JJ Charlesworth why neuroscience is having an influence in some areas of art appreciation.</p><p>Picture: The reflection of trees in water, Credit: Getty</p>

Alf Adams

<p>Alf Adams FRS, physicist at the University of Surrey, had an idea on a beach in the mid-eighties that made the modern internet, CD and DVD players, and even bar-code readers possible. You probably have half a dozen 'strained-layer quantum well lasers' in your home.</p><p>Image credit: Alf Adams, BBC Copyright</p>

Mark Miodownik

<p>Mark Miodownik's chronic interest in materials began in rather unhappy circumstances. He was stabbed in the back, with a razor, on his way to school. When he saw the tiny piece of steel that had caused him so much harm, he became obsessed with how it could it be so sharp and so strong. And he's been materials-mad ever since. </p><p>Working at a nuclear weapons laboratory in the US, he enjoyed huge budgets and the freedom to make the most amazing materials. But he gave that up to work with artists and designers because he believes that if you ignore the sensual aspects of materials, you end up with materials that people don't want. </p><p>For Mark, making is as important as reading and writing. It's an expression of who we are, like music or literature, and 'everyone should be doing it'. To this end, he wants our public libraries to be converted into public workshops, with laser cutters and 3 D printers in place of books.</p><p>Image: Mark Miodownik, BBC Copyright</p>

Sue Black

<p>Forensic anthropologist professor Sue Black began her career with a Saturday job working in a butcher's shop. At the time she didn't realise that this would be the start of a lifelong fascination with anatomy. Her job has taken her to some extreme and challenging locations to identify human bodies, such as Kosovo, where she uncovered evidence used in the UN's War Crimes Tribunal in The Hague. </p><p>Back home, Sue has been integral in solving many high-profile criminal cases, including cracking Scotland's biggest paedophile ring in 2009. </p><p>In The Life Scientific, Jim al-Khalili asks how she deals with the emotional pressures of the job, and why she is so fascinated by the inner workings of the human body. </p><p>In her spare time, Sue Black also advises crime fiction authors like Val McDermid, providing inspiration for new plotlines and characters. In return, Val and a group of writers have offered to help with Sue's latest challenge - fundraising for a mortuary. This facility will use new techniques to embalm bodies and promises to revolutionise the way surgeons are trained. </p><p>(Photo: Sue Black, BBC copyright)</p>

Whatever Happened to Biofuels - Part Two

<p>Whatever happened to biofuels? They were seen as the replacement for fossil fuels until it was realised they were being grown on land that should have been used for food crops. But now there is serious research into new ways of producing biofuels, from waste materials, from algae and from bacteria. </p><p>Gaia Vince takes to the water of Strangford Lough in Northern Ireland where Professor Matthew Dring and Dr Karen Mooney from Queens University, Belfast, are experimenting in growing algae that could be turned into fuel. She visits Professor Alison Smith's algae lab at Cambridge University. Graham Ellis from Solazyme in California explains how his company has already made fuel from algae that has been sold at the pumps and powered a plane, in a mixture with conventional fuel. And Professor Nick Turner at Manchester University and Professor John Love at Exeter University talk about how they are manipulating bacteria to make diesel.</p>

Whatever Happened to Biofuels?

<p>Biofuels were hailed as the environmental solution to fossil fuels not that long ago. Made from living crops they take up carbon dioxide as they grow. So burning them shouldn’t disturb the balance of warming gases in the atmosphere. </p><p>But for the last few years the publicity about biofuels has been mainly negative. And for good reason – biofuels are made from crops such as oil palm - grown in place of food crops or even rainforests. In some cases using these crops actually produces more CO2 than burning fossil fuels. However research is being done into new kinds of biofuels that aren’t in competition with food crops. </p><p>Gaia Vince travels to Bavaria in Germany to meet Dr Markus Rarbach, head of biofuels at Clariant. This company has set up a demonstration plant that produces ethanol from sugars in the waste products of wheat grown nearby. </p><p>Also on the programme is professor Gregory Tucker from Nottingham University who talks about research into new ways of getting sugars out of the inedible parts of crops; agricultural economist, Dr Paul Wilson, discusses what farmers think about making biofuels out of their straw; and Dr Angela Karp at Rothamsted Research, who is growing new willow varieties, which could be made into biofuels. </p><p>Image Credit: Clariant</p>

Peter Higgs

<p>An extended interview with the Nobel prize laureate. Peter Higgs tells Jim Al-Khalili that he failed to realise the full significance of the Higgs boson and to link it to the much celebrated Standard Model of Physics. He puts the oversight down to a string of missed opportunities, including one night at a physics summer camp when he chose to go to bed early. </p><p>Working alone in Edinburgh in the 1960s, Peter Higgs says he was considered "a bit of a crank... No-one wanted to work with me". In 1964, he predicted the possible existence of a new kind of boson but, at the time, there was little interest. </p><p>Three years later, the Higgs mechanism was shown to be central to the new Standard Model of Physics, which brings together three of the four fundamental forces of nature and has dominated physics ever since. Higgs met one of the key architects of the Standard Model several times, but they failed to realise they were working on the same thing. </p><p>The 1970s were an exciting time for particle physics but Higgs says he lacked technical competency. He adds that work pressure contributed to the breakdown of his marriage. Four decades and several billion pounds on, scientists at the Large Hadron Collider at CERN confirmed that the Higgs boson had indeed been found and Peter Higgs shot to fame. </p><p>This ephemeral speck of elusive energy is now so well-known it's featured in car adverts and countless jokes. There's even song by Nick Cave called the Higgs Boson Blues. But Higgs has always called it the 'scalar boson' and remains embarrassed that it is named after only him. He remains surprised that another British physicist, Tom Kibble from Imperial College, London didn't share the 2013 Nobel Prize for Physics along with him and Belgian physicist, Francois Englert. </p><p>These days, he's constantly stopped in the street and asked for autographs and photographs which, he says, is "nice but a bit of a nuisance". </p><p>Producer: Anna Buckley Image Credit: BBC</p>

Vikram Patel

<p>Jim al-Khalili talks to psychiatrist Vikram Patel about the global campaign he is leading to tackle mental health. He reflects on his early career working in Zimbabwe, when he doubted any western diagnosis or treatments for peoples' distress would be of much use. However, his subsequent research made him question this and come to the realisation that some conditions, like depression and psychosis, could be tackled universally. Now based in India, Vikram's research guides the public health approach he is taking. Yet critics question the application of Western categories for diagnosis and treatment to other parts of the world. </p><p>(Photo: Vikram Patel)</p>

Inside the Shark's Mind

<p>Fatal shark attacks on humans have been on the increase in Australia. For Discovery, marine biologist Dr Helen Scales finds out how scientists are exploring new, humane ways to reduce this number. At the start of this year, the state government of Western Australia decided to undertake the culling of sharks longer than three metres, after what they called an “unprecedented number of attacks”. In February, thousands of Australians protested against the cull, with conservationists claiming that it will make no difference to the number of attacks. </p><p>An outspoken critic of the strategy is Rodney Fox, who was almost killed by a Great White shark when he was a young man but who subsequently made a 50-year-long career filming sharks, shark tourism and shark conservation. Rodney talks to Helen about the day he was attacked and his thoughts about the Western Australian cull. Rodney argues that another approach is needed.</p><p>On a mission to reduce shark attacks, a team has been formed at the Ocean Institute, University of Western Australia (UWA). Their task is to think like a shark to understand how a shark’s brain perceives and reacts to light, sound and vibrations, and how the shark’s finely tuned senses might be manipulated in the hunt for more effective, humanitarian shark repellents. </p><p>Research revealed that Great Whites have large chunks of their brain dedicated to vision. So UWA are developing and testing a shark-proof wetsuit that mimics the appearance of poisonous, striped sea snakes. Other solutions under study include bubble curtains and the use of devices which generate electric fields around swimmers.</p><p>Helen also questions whether sharks deserve their reputation as the most fearsome predators of the sea. Have they been misunderstood and mythologised by popular culture through films such as Jaws and Deep Blue Sea. </p><p>Proving that even the most predatory of sharks are not automatic man-eaters, Helen herself goes diving with dozens of huge bull sharks (one of the most aggressive species) and comes to the surface unscathed. These three metre long monsters have been trained to be hand-fed by locals while tourists watch close by. </p><p>Helen also talks to veteran shark researcher Eugenie Clark about the predators’ learning abilities and intelligence. Dr Clark was able to train sharks to learn to press the correct buttons with their snouts to get a food treat. She even presented the Crown Prince of Japan with a baby nurse shark who never made a mistake.</p><p>(Photo: Courtesy of Helen Scales)</p>

The Biology of Freedom

<p>Is free will unique to humans or a biological trait that evolved over time and across species? Whilst the existence and nature of free will has been hotly debated by philosophers through the centuries, the basic idea that we determine our own destiny is fundamental to human experience. We can even decide to act in ways which may threaten our very existence. Biology underpins how we behave but it is the human mind that decides to act. Recently, however, this idea has come under attack from neuroscience research which has shown our sense of freedom to be something of an illusion. MRI scans suggest our brains make decisions several seconds before we are consciously aware of them. We have an ability to react to new situations, to be unpredictable and even illogical, to the point of self-destruction. But look closely and these qualities can also be found across the animal kingdom. From bonobos to bacteria, organisms are making what appear to be independent decisions in surprising ways. As part of the Freedom 2014 season, entomologist Adam Hart explores the biology of freedom, meeting researchers working with apes, birds, insects and even single-celled microbes, who are redefining the way we think about free will and its origins.</p><p>(Image Credit: Joshua Hart)</p>

Fructose: the Bittersweet Sugar

<p>If you believe the headlines fructose is 'addictive as cocaine', a 'toxic additive' or a 'metabolic danger'. So how has a simple sugar in fruit and honey got such a bad name and is there any evidence behind the accusations that it has caused the obesity epidemic? Meanwhile, a new health claim approved by the European Food Safety Authority for foods or drinks substituting fructose for other sugars, comes into force. </p><p>Dr Mark Porter talks to leading world experts to sift through the evidence in Fructose: The Bitter Sweet Sugar.</p><p>Picture: Ingredients list on a drinks bottle, Credit: Associated Press</p>