#133 – Manolis Kellis: Biology of Disease

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<p>Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:<br /> &#8211; <b>SEMrush</b>: <a href="https://www.semrush.com/partner/lex/">https://www.semrush.com/partner/lex/</a> to get a free month of Guru<br /> &#8211; <b>Pessimists Archive</b>: <a href="https://pessimists.co/">https://pessimists.co/</a><br /> &#8211; <b>Eight Sleep</b>: <a href="https://www.eightsleep.com/lex">https://www.eightsleep.com/lex</a> and use code LEX to get $200 off<br /> &#8211; <b>BetterHelp</b>: <a href="https://betterhelp.com/lex">https://betterhelp.com/lex</a> to get 10% off</p> <p><b>EPISODE LINKS:</b><br /> Manolis Website: <a href="http://web.mit.edu/manoli/">http://web.mit.edu/manoli/</a><br /> Manolis Twitter: <a href="https://twitter.com/manoliskellis">https://twitter.com/manoliskellis</a><br /> Manolis YouTube: <a href="https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA">https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA</a><br /> Manolis Wikipedia: <a href="https://en.wikipedia.org/wiki/Manolis_Kellis">https://en.wikipedia.org/wiki/Manolis_Kellis</a></p> <p><b>PODCAST INFO:</b><br /> Podcast website: <a href="https://lexfridman.com/podcast">https://lexfridman.com/podcast</a><br /> Apple Podcasts: <a href="https://apple.co/2lwqZIr">https://apple.co/2lwqZIr</a><br /> Spotify: <a href="https://spoti.fi/2nEwCF8">https://spoti.fi/2nEwCF8</a><br /> RSS: <a href="https://lexfridman.com/feed/podcast/">https://lexfridman.com/feed/podcast/</a><br /> YouTube Full Episodes: <a href="https://youtube.com/lexfridman">https://youtube.com/lexfridman</a><br /> YouTube Clips: <a href="https://youtube.com/lexclips">https://youtube.com/lexclips</a></p> <p><b>SUPPORT &#38; CONNECT:</b><br /> &#8211; Check out the sponsors above, it&#8217;s the best way to support this podcast<br /> &#8211; Support on Patreon: <a href="https://www.patreon.com/lexfridman">https://www.patreon.com/lexfridman</a><br /> &#8211; Twitter: <a href="https://twitter.com/lexfridman">https://twitter.com/lexfridman</a><br /> &#8211; Instagram: <a href="https://www.instagram.com/lexfridman">https://www.instagram.com/lexfridman</a><br /> &#8211; LinkedIn: <a href="https://www.linkedin.com/in/lexfridman">https://www.linkedin.com/in/lexfridman</a><br /> &#8211; Facebook: <a href="https://www.facebook.com/LexFridmanPage">https://www.facebook.com/LexFridmanPage</a><br /> &#8211; Medium: <a href="https://medium.com/@lexfridman">https://medium.com/@lexfridman</a></p> <p><b>OUTLINE:</b><br /> Here&#8217;s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.<br /> 00:00 &#8211; Introduction<br /> 08:05 &#8211; Molecular basis for human disease<br /> 32:04 &#8211; Deadliest diseases<br /> 37:47 &#8211; Genetic component of diseases<br /> 46:38 &#8211; Genetic understanding of disease<br /> 1:02:25 &#8211; Unified theory of human disease<br /> 1:08:26 &#8211; Genome circuitry<br /> 1:33:29 &#8211; CRISPR<br /> 1:45:06 &#8211; Mitochondria<br /> 1:53:10 &#8211; Future of biology research<br /> 2:22:46 &#8211; The genetic circuitry of disease</p>